COPG explained

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene.^{[1] [2]} It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.^[1]

Interactions

COPG has been shown to interact with Dopamine receptor D1,^[3] COPZ1^{[1] [4]} and COPB1.^{[1] [5]}

Further reading

• Lowe M, Kreis TE . In vivo assembly of coatomer, the COP-I coat precursor. . J. Biol. Chem. . 271 . 48 . 30725–30 . 1997 . 8940050 . 10.1074/jbc.271.48.30725 . free .
• Pavel J, Harter C, Wieland FT . Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 5 . 2140–5 . 1998 . 9482852 . 10.1073/pnas.95.5.2140 . 19276 . 1998PNAS...95.2140P . free .
• Fischer KD, Helms JB, Zhao L, Wieland FT . Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles. . Methods . 20 . 4 . 455–64 . 2000 . 10720466 . 10.1006/meth.2000.0958 .
• Eugster A, Frigerio G, Dale M, Duden R . COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. . EMBO J. . 19 . 15 . 3905–17 . 2000 . 10921873 . 10.1093/emboj/19.15.3905 . 306616 .
• Hu RM, Han ZG, Song HD . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . etal. 2000PNAS...97.9543H . free .
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V . RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. . Mol. Biol. Cell . 11 . 9 . 3155–68 . 2000 . 10982407 . 10.1091/mbc.11.9.3155. 14982 . etal.
• Hahn Y, Lee YJ, Yun JH . Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. . FEBS Lett. . 482 . 1–2 . 31–6 . 2000 . 11018518 . 10.1016/S0014-5793(00)02033-0 . 36356269 . etal.
• Paulsson KM, Kleijmeer MJ, Griffith J . Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum . J. Biol. Chem. . 277 . 21 . 18266–71 . 2002 . 11884415 . 10.1074/jbc.M201388200 . etal. free .
• Bermak JC, Li M, Bullock C . Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus . Eur. J. Cell Biol. . 81 . 2 . 77–85 . 2002 . 11893085 . 10.1078/0171-9335-00222 . etal.
• Kanzaki M, Watson RT, Hou JC . Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes . Mol. Biol. Cell . 13 . 7 . 2334–46 . 2003 . 12134073 . 10.1091/mbc.01-10-0490 . 117317 . etal.
• Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Mol. Biol. Cell . 13 . 10 . 3493–507 . 2003 . 12388752 . 10.1091/mbc.E02-01-0004 . 129961 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Rohde HM, Cheong FY, Konrad G . The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex . J. Biol. Chem. . 278 . 52 . 52689–99 . 2004 . 14527956 . 10.1074/jbc.M307983200 . etal. free .
• Watson PJ, Frigerio G, Collins BM . Gamma-COP appendage domain - structure and function . Traffic . 5 . 2 . 79–88 . 2004 . 14690497 . 10.1111/j.1600-0854.2004.00158.x . 24249308 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K . Identification and characterization of novel isoforms of COP I subunits . J Biochem . 128 . 5 . 793–801 . February 2001. 11056392 . 10.1093/oxfordjournals.jbchem.a022817.
2. Web site: Entrez Gene: COPG coatomer protein complex, subunit gamma.
3. Bermak . Jason C . Li Ming . Bullock Clayton . Weingarten Paul . Zhou Qun-Yong . February 2002. Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus . Eur. J. Cell Biol. . 81 . 2 . 77–85 . Germany. 0171-9335. 11893085 . 10.1078/0171-9335-00222 .
4. Faulstich . D . Auerbach S. Orci L. Ravazzola M. Wegchingel S. Lottspeich F. Stenbeck G. Harter C. Wieland F T. Tschochner H . October 1996. Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex . J. Cell Biol. . 135 . 1 . 53–61 . UNITED STATES. 0021-9525. 8858162 . 10.1083/jcb.135.1.53 . 2121028 .
5. Lowe . M . Kreis T E . November 1996. In vivo assembly of coatomer, the COP-I coat precursor . J. Biol. Chem. . 271 . 48 . 30725–30 . UNITED STATES. 0021-9258. 8940050 . 10.1074/jbc.271.48.30725 . free .