COPE (gene) explained

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.^{[1] [2]}

Function

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

COPE (gene) has been shown to interact with COPA.^{[3] [4] [5]}

References

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Orcl L, Palmer DJ, Amherdt M, Rothman JE . Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol . Nature . 364 . 6439 . 732–4 . 1993 . 8355790 . 10.1038/364732a0 . 1993Natur.364..732O . 4348442 .
• Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H . Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex . J. Cell Biol. . 135 . 1 . 53–61 . 1996 . 8858162 . 2121028 . 10.1083/jcb.135.1.53 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Pavel J, Harter C, Wieland FT . Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex . Proc. Natl. Acad. Sci. U.S.A. . 95 . 5 . 2140–5 . 1998 . 9482852 . 19276 . 10.1073/pnas.95.5.2140 . 1998PNAS...95.2140P . free .
• de La Vega LA, Stockert RJ . The cytoplasmic coatomer protein COPI. A potential translational regulator . J. Biol. Chem. . 274 . 44 . 31135–8 . 1999 . 10531302 . 10.1074/jbc.274.44.31135 . free .
• Eugster A, Frigerio G, Dale M, Duden R . COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP . EMBO J. . 19 . 15 . 3905–17 . 2000 . 10921873 . 306616 . 10.1093/emboj/19.15.3905 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Zhang T, Hong W . Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport . J. Biol. Chem. . 276 . 29 . 27480–7 . 2001 . 11323436 . 10.1074/jbc.M102786200 . free .
• Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Mol. Biol. Cell . 13 . 10 . 3493–507 . 2002 . 12388752 . 129961 . 10.1091/mbc.E02-01-0004 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Shima DT, Scales SJ, Kreis TE, Pepperkok R . Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes . Curr. Biol. . 9 . 15 . 821–4 . November 1999 . 10469566 . 10.1016/S0960-9822(99)80365-0 . 16182290 . free . 1999CBio....9..821S .
2. Web site: Entrez Gene: COPE coatomer protein complex, subunit epsilon.
3. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
4. Eugster A, Frigerio G, Dale M, Duden R . COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP . EMBO J. . 19 . 15 . 3905–17 . August 2000 . 10921873 . 306616 . 10.1093/emboj/19.15.3905 .
5. Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H . Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex . J. Cell Biol. . 135 . 1 . 53–61 . October 1996 . 8858162 . 2121028 . 10.1083/jcb.135.1.53 .