Collagen, type V, alpha 3 explained

Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene.^{[1] [2]}

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages.

Further reading

• van der Rest M, Garrone R . Collagen family of proteins . FASEB J. . 5 . 13 . 2814–23 . 1991 . 1916105 . 10.1096/fasebj.5.13.1916105. free . 11261357 .
• Fichard A, Kleman JP, Ruggiero F . Another look at collagen V and XI molecules . Matrix Biol. . 14 . 7 . 515–31 . 1996 . 8535602 . 10.1016/S0945-053X(05)80001-0 .
• Mann K . Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing . Biol. Chem. Hoppe-Seyler . 373 . 2 . 69–75 . 1992 . 1571108 . 10.1515/bchm3.1992.373.1.69 .
• Niyibizi C, Fietzek PP, van der Rest M . Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule . J. Biol. Chem. . 259 . 22 . 14170–4 . 1984 . 10.1016/S0021-9258(18)89872-6 . 6501291 . free .
• Abedin MZ, Ayad S, Weiss JB . Isolation and native characterization of cysteine-rich collagens from bovine placental tissues and uterus and their relationship to types IV and V collagens . Biosci. Rep. . 2 . 7 . 493–502 . 1982 . 7115902 . 10.1007/BF01115247 . 22620593 .
• Rhodes RK, Miller EJ . Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule in human placental tissue . Coll. Relat. Res. . 1 . 4 . 337–43 . 1982 . 7346227 . 10.1016/S0174-173X(81)80010-6.
• Kypreos KE, Sonenshein GE . Basic fibroblast growth factor decreases type V/XI collagen expression in cultured bovine aortic smooth muscle cells . J. Cell. Biochem. . 68 . 2 . 247–58 . 1998 . 9443080 . 10.1002/(SICI)1097-4644(19980201)68:2<247::AID-JCB11>3.0.CO;2-C . 19211563 . free .
• Chanut-Delalande H, Fichard A, Bernocco S . Control of heterotypic fibril formation by collagen V is determined by chain stoichiometry . J. Biol. Chem. . 276 . 26 . 24352–9 . 2001 . 11423559 . 10.1074/jbc.M101182200 . etal. free .
• Gopalakrishnan B, Wang WM, Greenspan DS . Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer . J. Biol. Chem. . 279 . 29 . 30904–12 . 2004 . 15136578 . 10.1074/jbc.M402252200 . free .
• Nagato H, Matsuo N, Sumiyoshi H . The transcription factor CCAAT-binding factor CBF/NF-Y and two repressors regulate the core promoter of the human pro-alpha3(V) collagen gene (COL5A3) . J. Biol. Chem. . 279 . 45 . 46373–83 . 2004 . 15316020 . 10.1074/jbc.M406069200 . etal. free .

Notes and References

1. Imamura Y, Scott IC, Greenspan DS . The pro-alpha3(V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains . J Biol Chem . 275 . 12 . 8749–59 . Apr 2000 . 10722718 . 10.1074/jbc.275.12.8749 . free .
2. Web site: Entrez Gene: COL5A3 collagen, type V, alpha 3.