COG8 explained

Conserved oligomeric Golgi complex subunit 8 is a protein that in humans is encoded by the COG8 gene.^{[1] [2]}

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi complex (COG), which includes COG8 (Ungar et al., 2002).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Pellizzoni L, Charroux B, Rappsilber J . A functional interaction between the survival motor neuron complex and RNA polymerase II . J. Cell Biol. . 152 . 1 . 75–85 . 2001 . 11149922 . 10.1083/jcb.152.1.75 . 2193649 . etal.
• Venter JC, Adams MD, Myers EW . The sequence of the human genome . Science . 291 . 5507 . 1304–51 . 2001 . 11181995 . 10.1126/science.1058040 . 2001Sci...291.1304V . etal. free .
• Whyte JR, Munro S . The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic . Dev. Cell . 1 . 4 . 527–37 . 2001 . 11703943 . 10.1016/S1534-5807(01)00063-6 . free .
• Loh E, Hong W . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp . J. Biol. Chem. . 277 . 24 . 21955–61 . 2002 . 11929878 . 10.1074/jbc.M202326200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Loh E, Hong W . The binary interacting network of the conserved oligomeric Golgi tethering complex . J. Biol. Chem. . 279 . 23 . 24640–8 . 2004 . 15047703 . 10.1074/jbc.M400662200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

Notes and References

1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG . Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function . J Cell Biol . 157 . 3 . 405–15 . Apr 2002 . 11980916 . 2173297 . 10.1083/jcb.200202016 .
2. Web site: Entrez Gene: COG8 component of oligomeric golgi complex 8.