COG7 explained

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.^{[1] [2]}

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM]^[2]

Interactions

COG7 has been shown to interact with COG4^[3] and COG5.^[3]

Further reading

• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Loh E, Hong W . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. . J. Biol. Chem. . 277 . 24 . 21955–61 . 2002 . 11929878 . 10.1074/jbc.M202326200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Loh E, Hong W . The binary interacting network of the conserved oligomeric Golgi tethering complex. . J. Biol. Chem. . 279 . 23 . 24640–8 . 2004 . 15047703 . 10.1074/jbc.M400662200 . free .
• Wu X, Steet RA, Bohorov O . Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. . Nat. Med. . 10 . 5 . 518–23 . 2004 . 15107842 . 10.1038/nm1041 . 29322859 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Oka T, Vasile E, Penman M . Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. . J. Biol. Chem. . 280 . 38 . 32736–45 . 2005 . 16051600 . 10.1074/jbc.M505558200 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Steet R, Kornfeld S . COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins. . Mol. Biol. Cell . 17 . 5 . 2312–21 . 2006 . 16510524 . 10.1091/mbc.E05-08-0822 . 1446086 .
• Morava E, Zeevaert R, Korsch E . A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. . Eur. J. Hum. Genet. . 15 . 6 . 638–45 . 2007 . 17356545 . 10.1038/sj.ejhg.5201813 . etal. free .

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

Notes and References

1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG . Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function . J Cell Biol . 157 . 3 . 405–15 . Apr 2002 . 11980916 . 2173297 . 10.1083/jcb.200202016 .
2. Web site: Entrez Gene: COG7 component of oligomeric golgi complex 7.
3. Loh . Eva . Hong Wanjin . Jun 2004 . The binary interacting network of the conserved oligomeric Golgi tethering complex . J. Biol. Chem. . 279 . 23 . 24640–8 . 0021-9258. 15047703 . 10.1074/jbc.M400662200 . free .