COG3 explained

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.^{[1] [2]}

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.

Interactions

COG3 has been shown to interact with COG2^[3] and COG1.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S . High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking . Molecular Biology of the Cell . 10 . 10 . 3317–29 . October 1999 . 10512869 . 25597 . 10.1091/mbc.10.10.3317 .
• VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG . Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p . The Journal of Cell Biology . 147 . 4 . 729–42 . November 1999 . 10562277 . 2156162 . 10.1083/jcb.147.4.729 .
• Suvorova ES, Kurten RC, Lupashin VV . Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery . The Journal of Biological Chemistry . 276 . 25 . 22810–8 . June 2001 . 11292827 . 10.1074/jbc.M011624200 . free .
• Loh E, Hong W . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp . The Journal of Biological Chemistry . 277 . 24 . 21955–61 . June 2002 . 11929878 . 10.1074/jbc.M202326200 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Loh E, Hong W . The binary interacting network of the conserved oligomeric Golgi tethering complex . The Journal of Biological Chemistry . 279 . 23 . 24640–8 . June 2004 . 15047703 . 10.1074/jbc.M400662200 . free .

Notes and References

1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG . Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function . The Journal of Cell Biology . 157 . 3 . 405–15 . April 2002 . 11980916 . 2173297 . 10.1083/jcb.200202016 .
2. Web site: Entrez Gene: COG3 component of oligomeric golgi complex 3.
3. Loh E, Hong W . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp . The Journal of Biological Chemistry . 277 . 24 . 21955–61 . June 2002 . 11929878 . 10.1074/jbc.M202326200 . free .