COG2 explained

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.^{[1] [2]} Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).^[3]

Interactions

COG2 has been shown to interact with COG4^[4] and COG3.^[5]

Further reading

• Salesiotis AN, Wang CK, Wang CD . Identification of novel genes from stomach cancer cell lines by differential display. . Cancer Lett. . 91 . 1 . 47–54 . 1995 . 7750094 . 10.1016/0304-3835(95)03717-B . etal.
• Loh E, Hong W . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. . J. Biol. Chem. . 277 . 24 . 21955–61 . 2002 . 11929878 . 10.1074/jbc.M202326200 . free .
• Ungar D, Oka T, Brittle EE . Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. . J. Cell Biol. . 157 . 3 . 405–15 . 2002 . 11980916 . 10.1083/jcb.200202016 . 2173297 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Loh E, Hong W . The binary interacting network of the conserved oligomeric Golgi tethering complex. . J. Biol. Chem. . 279 . 23 . 24640–8 . 2004 . 15047703 . 10.1074/jbc.M400662200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Sohda M, Misumi Y, Yoshimura S . The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity. . Traffic . 8 . 3 . 270–84 . 2007 . 17274799 . 10.1111/j.1600-0854.2006.00530.x . etal. free .

Notes and References

1. Podos SD, Reddy P, Ashkenas J, Krieger M . LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function . J Cell Biol . 127 . 3 . 679–91 . Dec 1994 . 7962052 . 2120235 . 10.1083/jcb.127.3.679 .
2. Web site: Entrez Gene: COG2 component of oligomeric golgi complex 2.
3. Web site: Entrez Gene: COG2 component of oligomeric golgi complex 2.
4. Loh . Eva . Hong Wanjin . Jun 2004 . The binary interacting network of the conserved oligomeric Golgi tethering complex . J. Biol. Chem. . 279 . 23 . 24640–8 . 0021-9258. 15047703 . 10.1074/jbc.M400662200 . free .
5. Loh . Eva . Hong Wanjin . Jun 2002 . Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp . J. Biol. Chem. . 277 . 24 . 21955–61 . 0021-9258. 11929878 . 10.1074/jbc.M202326200 . free .