CNTROB explained

Centrobin is a protein that in humans is encoded by the CNTROB gene.^[1] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.^[2]

Further reading

• Jeong Y, Lee J, Kim K . Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization. . J. Cell Sci. . 120 . Pt 12 . 2106–16 . 2007 . 17535851 . 10.1242/jcs.03458 . etal. free .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .
• Wan D, Gong Y, Qin W . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .

Notes and References

1. 11984006. 2002. Tchernev . V. T.. Mansfield . T. A.. Giot . L.. Kumar . A. M.. Nandabalan . K.. Li . Y.. Mishra . V. S.. Detter . J. C.. Rothberg . J. M.. Wallace . M. R.. Southwick . F. S.. Kingsmore . S. F.. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. 8. 1. 56–64. 2039936. Molecular Medicine . 10.1007/bf03402003.
2. 10.1083/jcb.200506185. 16275750. 2005. Zou . C.. Li . J.. Bai . Y.. Gunning . W.. Wazer . D.. Band . V.. Gao . Q.. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. 171. 3. 437–445. 2171251. Journal of Cell Biology.