CNTRL explained

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.^{[1] [2]}

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.^[2]

Further reading

• Gromley A, Yeaman C, Rosa J . Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. . Cell . 123 . 1 . 75–87 . 2005 . 16213214 . 10.1016/j.cell.2005.07.027 . 6665005 . etal. free .
• Guinn BA, Bland EA, Lodi U . Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. . Biochem. Biophys. Res. Commun. . 335 . 4 . 1293–304 . 2005 . 16112646 . 10.1016/j.bbrc.2005.08.024 . etal.
• Jurczyk A, Gromley A, Redick S . Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. . J. Cell Biol. . 166 . 5 . 637–43 . 2004 . 15337773 . 10.1083/jcb.200405023 . 2172416 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gromley A, Jurczyk A, Sillibourne J . A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. . J. Cell Biol. . 161 . 3 . 535–45 . 2003 . 12732615 . 10.1083/jcb.200301105 . 2172935 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ou YY, Mack GJ, Zhang M, Rattner JB . CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. . J. Cell Sci. . 115 . Pt 9 . 1825–35 . 2002 . 10.1242/jcs.115.9.1825 . 11956314 .
• Popovici C, Mattéi MG, Rattner JB . Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization. . Cytogenet. Cell Genet. . 89 . 3–4 . 216–7 . 2000 . 10965126 . 10.1159/000015616 . 31717030 . etal.
• Osaki E, Nishina Y, Inazawa J . Identification of a novel Sry-related gene and its germ cell-specific expression . Nucleic Acids Res. . 27 . 12 . 2503–10 . 1999 . 10359848 . 10.1093/nar/27.12.2503 . 148454 . etal.
• Schütze S, Machleidt T, Adam D . Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling . J. Biol. Chem. . 274 . 15 . 10203–12 . 1999 . 10187805 . 10.1074/jbc.274.15.10203 . etal. free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ . FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33) . Blood . 95 . 5 . 1788–96 . Mar 2000 . 10688839 . 10.1182/blood.V95.5.1788.005k15_1788_1796.
2. Web site: Entrez Gene: CEP110 centrosomal protein 110kDa.