Contactin 6 Explained

Contactin 6 is a protein in humans that is encoded by the CNTN6 gene.^[1]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.

Further reading

• Manderson EN, Birch AH, Shen Z, Mes-Masson AM, Provencher D, Tonin PN . Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer . International Journal of Gynecological Cancer . 19 . 4 . 513–25 . May 2009 . 19509545 . 10.1111/IGC.0b013e3181a3cd38 . 27315616 .
• Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H . A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa . Molecular Psychiatry . 16 . 9 . 949–59 . September 2011 . 21079607 . 3859494 . 10.1038/mp.2010.107 .
• Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM . Genome-wide association of lipid-lowering response to statins in combined study populations . PLOS ONE . 5 . 3 . e9763 . March 2010 . 20339536 . 2842298 . 10.1371/journal.pone.0009763 . 2010PLoSO...5.9763B . Zanger . Ulrich . free .
• Kamei Y, Tsutsumi O, Taketani Y, Watanabe K . cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human . Journal of Neuroscience Research . 51 . 3 . 275–83 . February 1998 . 9486763 . 10.1002/(SICI)1097-4547(19980201)51:3<275::AID-JNR1>3.0.CO;2-D . 43122787 .
• Walsh FS, Doherty P . Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system . Cell Biology International Reports . 15 . 11 . 1151–66 . November 1991 . 1838307 . 10.1016/0309-1651(91)90061-M .
• Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC . Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization . The EMBO Journal . 22 . 21 . 5666–78 . November 2003 . 14592966 . 275427 . 10.1093/emboj/cdg570 .
• Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X . Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients . Journal of Psychiatric Research . 44 . 14 . 971–8 . October 2010 . 20398908 . 10.1016/j.jpsychires.2010.03.007 .

Notes and References

1. Web site: Entrez Gene: Contactin 6 .