Contactin 1 Explained

Contactin 1 (CNTN1) is a protein which in humans is encoded by the CNTN1 gene.[1] [2]

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

CNTN1 has been shown to interact with PTPRB.[3] [4]

Further reading

Notes and References

  1. Berglund EO, Ranscht B . Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12 . Genomics . 21 . 3 . 571–82 . Jun 1994 . 7959734 . 10.1006/geno.1994.1316 .
  2. Web site: Entrez Gene: CNTN1 contactin 1.
  3. Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M . Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta . The Journal of Cell Biology . 136 . 4 . 907–18 . Feb 1997 . 9049255 . 2132488 . 10.1083/jcb.136.4.907 .
  4. Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J . The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin . Cell . 82 . 2 . 251–60 . Jul 1995 . 7628014 . 10.1016/0092-8674(95)90312-7 . 18084292 . free .