CNOT9 explained

CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene.^[1]

Function

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].

Further reading

• Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H . Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation . EMBO J. . 21 . 19 . 5235–44 . October 2002 . 12356739 . 129043 . 10.1093/emboj/cdf521 .
• Garapaty S, Mahajan MA, Samuels HH . Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1 . J. Biol. Chem. . 283 . 11 . 6806–16 . March 2008 . 18180299 . 10.1074/jbc.M706986200 . free .
• Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T, Daigo Y, Nakamura Y . Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells . Int. J. Oncol. . 35 . 4 . 673–81 . October 2009 . 19724902 .
• Ajiro M, Nishidate T, Katagiri T, Nakamura Y . Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis . Int. J. Oncol. . 37 . 5 . 1085–93 . November 2010 . 20878056 . 10.3892/ijo_00000760 . free .
• Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W . Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression . Mol. Cell . 54 . 5 . 751–65 . June 2014 . 24768538 . 10.1016/j.molcel.2014.03.036 . free .
• Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E . A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing . Mol. Cell . 54 . 5 . 737–50 . June 2014 . 24768540 . 10.1016/j.molcel.2014.03.034 . free .
• Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, Sheppard KE, Wolfe R, Kelly J, Cebon J, Dobrovic A, McArthur GA . Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma . Oncotarget . 6 . 2 . 1115–27 . January 2015 . 25544760 . 4359221 . 10.18632/oncotarget.2747 .
• Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, ((Dean JLE)) . Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment . J. Mol. Biol. . 430 . 5 . 722–736 . March 2018 . 29291391 . 10.1016/j.jmb.2017.12.018 .
• Han J, Yu J, Dai Y, Li J, Guo M, Song J, Zhou X . Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway . Bosn J Basic Med Sci . 19 . 1 . 52–59 . February 2019 . 29924958 . 6387672 . 10.17305/bjbms.2018.3399 .

Notes and References

1. Web site: Entrez Gene: CCR4-NOT transcription complex subunit 9. 2020-04-15.