CNOT6L explained

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.^[1] It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

Further reading

• Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T . Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth . Mol. Cell. Biol. . 27 . 13 . 4980–90 . July 2007 . 17452450 . 1951489 . 10.1128/MCB.02304-06 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z . Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity . EMBO J. . 29 . 15 . 2566–76 . August 2010 . 20628353 . 2928688 . 10.1038/emboj.2010.152 .
• Naylor MG, Weiss ST, Lange C . A Bayesian approach to genetic association studies with family-based designs . Genet. Epidemiol. . 34 . 6 . 569–74 . September 2010 . 20818722 . 3349938 . 10.1002/gepi.20513 .
• Mittal S, Aslam A, Doidge R, Medica R, Winkler GS . The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence . Mol. Biol. Cell . 22 . 6 . 748–58 . March 2011 . 21233283 . 3057700 . 10.1091/mbc.E10-11-0898 .
• Zhou W, Thiery JP . Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1 . J. Cell Sci. . 126 . Pt 12 . 2740–6 . June 2013 . 23591815 . 10.1242/jcs.126367 . free .
• Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C . Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation . Biochim. Biophys. Acta . 1863 . 2 . 263–70 . February 2016 . 26608607 . 10.1016/j.bbamcr.2015.11.018 . free .
• Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M . Structural basis for inhibition of the deadenylase activity of human CNOT6L . FEBS Lett. . 590 . 8 . 1270–9 . April 2016 . 27013054 . 10.1002/1873-3468.12160 . free .
• Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N . Hepatic posttranscriptional network CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis . Proc. Natl. Acad. Sci. U.S.A. . 116 . 16 . 7973–7981 . April 2019 . 30926667 . 6475422 . 10.1073/pnas.1816023116 . free .

Notes and References

1. Web site: Entrez Gene: CCR4-NOT transcription complex subunit 6 like. 2020-04-15.