CNOT6 explained
CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.[1] [2]
The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.
Further reading
- Okubo K, Itoh K, Fukushima A . Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. . Genomics . 30 . 2 . 178–86 . 1996 . 8586417 . 10.1006/geno.1995.9887 . etal.
- Nagase T, Ishikawa K, Kikuno R . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . etal. free .
- Albert TK, Lemaire M, van Berkum NL . Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. . Nucleic Acids Res. . 28 . 3 . 809–17 . 2000 . 10637334 . 10.1093/nar/28.3.809 . 102560 . etal.
- Dupressoir A, Morel AP, Barbot W . Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. . BMC Genomics . 2 . 9 . 2003 . 11747467 . 10.1186/1471-2164-2-9 . 61044 . etal . free .
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
- Chang TC, Yamashita A, Chen CY . UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. . Genes Dev. . 18 . 16 . 2010–23 . 2004 . 15314026 . 10.1101/gad.1219104 . 514181 . etal.
- Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
Notes and References
- Chen J, Chiang YC, Denis CL . CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase . EMBO J . 21 . 6 . 1414–26 . Mar 2002 . 11889047 . 125924 . 10.1093/emboj/21.6.1414 .
- Web site: Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6.