CNOT4 explained
CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[1]
Function
The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[2]
Further reading
- Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M . Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells . FASEB Journal . 26 . 3 . 1239–50 . March 2012 . 22159038 . 10.1096/fj.11-195875 . free . 25618632 .
- Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT . An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair . Journal of Molecular Biology . 337 . 1 . 157–65 . March 2004 . 15001359 . 10.1016/j.jmb.2004.01.031 .
- Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT . Human Ccr4-Not complexes contain variable deadenylase subunits . The Biochemical Journal . 422 . 3 . 443–53 . September 2009 . 19558367 . 10.1042/BJ20090500 .
- Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT . Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex . The EMBO Journal . 21 . 3 . 355–64 . February 2002 . 11823428 . 125831 . 10.1093/emboj/21.3.355 .
- Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R . Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches . Structure . 12 . 4 . 633–44 . April 2004 . 15062086 . 10.1016/j.str.2004.03.004 . free .
- Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants . Molecular Vision . 8 . 205–20 . June 2002 . 12107410 .
- Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD . Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression . Genes & Development . 23 . 8 . 951–62 . April 2009 . 19346402 . 2675863 . 10.1101/gad.1769209 .
- Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R . The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers . The Journal of Biological Chemistry . 276 . 13 . 10185–90 . March 2001 . 11087754 . 10.1074/jbc.M009298200 . free .
- Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT . Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits . Nucleic Acids Research . 28 . 3 . 809–17 . February 2000 . 10637334 . 102560 . 10.1093/nar/28.3.809 .
Notes and References
- Web site: Entrez Gene: CCR4-NOT transcription complex, subunit 4 .
- Web site: CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody. www.genecards.org. 2019-06-21.