CNOT2 explained

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene.^{[1] [2]} It is a subunit of the CCR4-Not deadenylase complex.

Further reading

• Zhang QH, Ye M, Wu XY . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zwartjes CG, Jayne S, van den Berg DL, Timmers HT . Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. . J. Biol. Chem. . 279 . 12 . 10848–54 . 2004 . 14707134 . 10.1074/jbc.M311747200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Shi J, Nelson MA . The cyclin-dependent kinase 11 interacts with NOT2. . Biochem. Biophys. Res. Commun. . 334 . 4 . 1310–6 . 2005 . 16039607 . 10.1016/j.bbrc.2005.07.026 .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Jayne S, Zwartjes CG, van Schaik FM, Timmers HT . Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. . Biochem. J. . 398 . 3 . 461–7 . 2006 . 16712523 . 10.1042/BJ20060406 . 1559471 .

Notes and References

1. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT . Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits . Nucleic Acids Res . 28 . 3 . 809–17 . Mar 2000 . 10637334 . 102560 . 10.1093/nar/28.3.809 .
2. Web site: Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2.