CNOT1 explained
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[1] [2]
It is a part of the CCR4-Not complex, which deadenylates mRNAs.[3] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[4] [5] [6]
Interactions
CNOT1 has been shown to interact with CNOT8.[7] [8]
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
- Chen J, Rappsilber J, Chiang YC, Russell P, Mann M, Denis CL . Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex . J. Mol. Biol. . 314 . 4 . 683–94 . 2001 . 11733989 . 10.1006/jmbi.2001.5162 .
- Laveder P, De Pittà C, Toppo S, Valle G, Lanfranchi G . A two-step strategy for constructing specifically self-subtracted cDNA libraries . Nucleic Acids Res. . 30 . 9 . 38e–38 . 2002 . 11972353 . 113861 . 10.1093/nar/30.9.e38 .
- Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT . Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription . EMBO J. . 25 . 13 . 3089–99 . 2006 . 16778766 . 1500986 . 10.1038/sj.emboj.7601194 .
Notes and References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S. 6 . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nature Genetics . 36 . 1 . 40–5 . January 2004 . 14702039 . 10.1038/ng1285 . free .
- Web site: Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1.
- Garneau NL, Wilusz J, Wilusz CJ . The highways and byways of mRNA decay . Nat. Rev. Mol. Cell Biol. . 8 . 2 . 113–26 . Feb 2007 . 17245413 . 10.1038/nrm2104 . 14107577 .
- Sandler H, Kreth J, Timmers HT, Stoecklin G . Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin . Nucleic Acids Res. . 39 . 10 . 4373–86 . May 2011 . 21278420 . 3105394 . 10.1093/nar/gkr011 .
- Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O . The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex . Nucleic Acids Res. . 40 . 21 . 11058–72 . Nov 2012 . 22977175 . 3510486 . 10.1093/nar/gks883 .
- Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E . Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction . Mol. Cell . 48 . 2 . 207–18 . Oct 26, 2012 . 22959269 . 10.1016/j.molcel.2012.08.014 . free .
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
- Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT . Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits . Nucleic Acids Res. . 28 . 3 . 809–17 . February 2000 . 10637334 . 102560 . 10.1093/nar/28.3.809 .
