Cytosol nonspecific dipeptidase explained

Cytosol nonspecific dipeptidase
Ec Number:	3.4.13.18
Cas Number:	9025-31-4

Cytosolic non-specific dipeptidase also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.^{[1] [2] [3]} This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.^[4] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".^[5]

See also

• N-lactoyl-phenylalanine, a chemical compound produced by this enzyme

Notes and References

1. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T . 6 . Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase . The Journal of Biological Chemistry . 278 . 8 . 6521–6531 . February 2003 . 12473676 . 10.1074/jbc.M209764200 . free .
2. Web site: Entrez Gene: CNDP2 carnosine dipeptidase 2.
3. Book: Cytosol non-specific dipeptidase . Handbook of Proteolytic Enzymes . Bauer K . 1998 . 1520–1522 . Barrett AJ, Rawlings ND, Woessner JF . Academic Press . London .
4. Web site: UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens.
5. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, Ijlst L, Wanders RJ, Borst P, van de Wetering K . 6 . N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids . Proceedings of the National Academy of Sciences of the USA . 112 . 21 . 6601–6606 . May 11, 2015 . 25964343 . 10.1073/pnas.1424638112 . free . 4450436 . 2015PNAS..112.6601J .