CMX521 explained

CMX521 is an antiviral drug discovered by Chimerix, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotovirus and some sapoviruses, astroviruses and adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase.^{[1] [2] [3]}

See also

• GS-441524
• NITD008
• Sangivamycin

Notes and References

1. Bassetto M, Van Dycke J, Neyts J, Brancale A, Rocha-Pereira J . Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy . Viruses . 11 . 2 . 173 . February 2019 . 30791582 . 6409847 . 10.3390/v11020173 . free .
2. Netzler NE, Enosi Tuipulotu D, White PA . Norovirus antivirals: Where are we now? . Medicinal Research Reviews . 39 . 3 . 860–886 . May 2019 . 30584800 . 7168425 . 10.1002/med.21545 .
3. Ebenezer O, Jordaan MA, Damoyi N, Shapi M . Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics . International Journal of Molecular Sciences . 22 . 1 . December 2020 . 171 . 33375298 . 7795727 . 10.3390/ijms22010171 . free .