CMV polyradiculomyelopathy explained

Specialty:neurology

CMV polyradiculomyelopathy (PRAM) is one of the five distinct neurological syndromes caused by CMV in HIV/AIDS. It causes subacute ascending lower extremity weakness with paresthesias and radicular pain, hyporeflexia or areflexia,[1] and urinary retention.[2] It has been suggested that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while taking either of these drugs.[3]

Notes and References

  1. Cohen. B. A.. McArthur. J. C.. Grohman. S.. Patterson. B.. Glass. J. D.. Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS. Neurology. 1 March 1993. 43. 3, Part 1. 493–9. 10.1212/WNL.43.3_Part_1.493. 8383823. 27051898.
  2. Guiot. HM. Pita-García. IL. Bertrán-Pasarell. J. Alfonso. G. Cytomegalovirus polyradiculomyelopathy in AIDS: a case report and review of the literature. Puerto Rico Health Sciences Journal. December 2006. 25. 4. 359–62. 17550105.
  3. Book: Neurotropic Viral Infections . . Reiss, Carol . 2008 . 355. 9781139474160 .

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