CLPTM1L explained

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene.^{[1] [2]} CRR9p is associated with cisplatin-induced apoptosis.^[2] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL.^[3] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.^[4]

See also

• Cleft lip and palate transmembrane protein 1

References

Further reading

• Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, Stoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher CJ, Zienolddiny S, Haugen A, van der Heijden HF, Kiemeney LA, Isla D, Mayordomo JI, Rafnar T, Stefansson K, Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner H, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay JD, Brennan P, Spitz MR . Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. . J. Natl. Cancer Inst. . 102 . 13 . 959–71 . 2010 . 20548021 . 2897877 . 10.1093/jnci/djq178.
• McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P . Lung cancer susceptibility locus at 5p15.33. . Nat. Genet. . 40 . 12 . 1404–6 . 2008 . 18978790 . 2748187 . 10.1038/ng.254.
• Wang Y, Broderick P, Matakidou A, Eisen T, Houlston RS . Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. . Carcinogenesis . 31 . 2 . 234–8 . 2010 . 19955392 . 10.1093/carcin/bgp287. free .
• Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, Matakidou A, Qureshi M, Dong Q, Gu X, Chen WV, Spitz MR, Eisen T, Amos CI, Houlston RS . Common 5p15.33 and 6p21.33 variants influence lung cancer risk. . Nat. Genet. . 40 . 12 . 1407–9 . 2008 . 18978787 . 2695928 . 10.1038/ng.273.
• Jin G, Xu L, Shu Y, Tian T, Liang J, Xu Y, Wang F, Chen J, Dai J, Hu Z, Shen H . Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. . Carcinogenesis . 30 . 6 . 987–90 . 2009 . 19369581 . 10.1093/carcin/bgp090. free .
• Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, Spitz MR, Eisen T, Amos CI, Houlston RS . Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. . Cancer Res. . 69 . 16 . 6633–41 . 2009 . 19654303 . 2754318 . 10.1158/0008-5472.CAN-09-0680.
• Liu Z, Li G, Wei S, Niu J, Wang LE, Sturgis EM, Wei Q . Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. . Carcinogenesis . 31 . 11 . 1977–1981 . 2010 . 20802237 . 2966556 . 10.1093/carcin/bgq179.
• Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ . A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. . Nat. Genet. . 42 . 3 . 224–8 . 2010 . 20101243 . 2853179 . 10.1038/ng.522.
• Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC . Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. . Mol. Psychiatry . 14 . 11 . 1004–16 . 2009 . 19204726 . 2860783 . 10.1038/mp.2009.10.
• Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, Sigurdsson A, Gudbjartsson DF, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Scherer D, Hemminki K, Rudnai P, Gurzau E, Koppova K, Botella-Estrada R, Soriano V, Juberias P, Saez B, Gilaberte Y, Fuentelsaz V, Corredera C, Grasa M, Höiom V, Lindblom A, Bonenkamp JJ, van Rossum MM, Aben KK, de Vries E, Santinami M, Di Mauro MG, Maurichi A, Wendt J, Hochleitner P, Pehamberger H, Gudmundsson J, Magnusdottir DN, Gretarsdottir S, Holm H, Steinthorsdottir V, Frigge ML, Blondal T, Saemundsdottir J, Bjarnason H, Kristjansson K, Bjornsdottir G, Okamoto I, Rivoltini L, Rodolfo M, Kiemeney LA, Hansson J, Nagore E, Mayordomo JI, Kumar R, Karagas MR, Nelson HH, Gulcher JR, Rafnar T, Thorsteinsdottir U, Olafsson JH, Kong A, Stefansson K . New common variants affecting susceptibility to basal cell carcinoma. . Nat. Genet. . 41 . 8 . 909–14 . 2009 . 19578363 . 2973331 . 10.1038/ng.412.
• Turnbull C, Rapley EA, Seal S, Pernet D, Renwick A, Hughes D, Ricketts M, Linger R, Nsengimana J, Deloukas P, Huddart RA, Bishop DT, Easton DF, Stratton MR, Rahman N . Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. . Nat. Genet. . 42 . 7 . 604–7 . 2010 . 20543847 . 10.1038/ng.607. 3773909 .
• Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang Z, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang Y, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metspalu A, Metsapalu A, Vooder T, Nelis M, Välk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeböller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE . A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. . Am. J. Hum. Genet. . 85 . 5 . 679–91 . 2009 . 19836008 . 2775843 . 10.1016/j.ajhg.2009.09.012.

Notes and References

1. Web site: Entrez Gene: CLPTM1-like .
2. Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y . A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. . Biochem Biophys Res Commun . 280 . 4 . 1148–54 . Feb 2001 . 11162647 . 10.1006/bbrc.2001.4250.
3. James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M . Functional Characterization of CLPTM1L as a Lung . PLOS ONE . 7 . 6 . 63116 . 2012 . 22675468 . 3366984 . 10.1371/journal.pone.0036116. free .
4. James MA, Vikis HG, Tate E, Rymaszewski AL, et al. . CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. . Cancer Res . 74 . 4 . 1116–27 . 2014 . 24366883 . 6005686 . 10.1158/0008-5472.CAN-13-1617.