CLNS1A explained

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.^{[1] [2] [3]}

Interactions

CLNS1A has been shown to interact with:

• ITGA2B,^[4]
• PRMT5,^{[5] [6] [7]}
• SNRPD1,^[8] and
• SNRPD3.^[8]

See also

• Chloride channel

Further reading

• Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P . New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium . Front. Biosci. . 11 . 1646–66 . 2006 . 16368544 . 10.2741/1911 . 26325962 . free .
• Buyse G, de Greef C, Raeymaekers L, Droogmans G, Nilius B, Eggermont J . The ubiquitously expressed pICln protein forms homomeric complexes in vitro . Biochem. Biophys. Res. Commun. . 218 . 3 . 822–7 . 1996 . 8579598 . 10.1006/bbrc.1996.0146 . free .
• Schwartz RS, Rybicki AC, Nagel RL . Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin . Biochem. J. . 327 . 2 . 609–16 . 1997 . 9359436 . 1218836 . 10.1042/bj3270609.
• Bekri S, Adélaïde J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pébusque MJ, Theillet C, Birnbaum D, Gaudray P . Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma . Cytogenet. Cell Genet. . 79 . 1–2 . 125–31 . 1998 . 9533029 . 10.1159/000134699 .
• Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE . pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology . J. Biol. Chem. . 273 . 18 . 10811–4 . 1998 . 9556550 . 10.1074/jbc.273.18.10811 . free .
• Tang CJ, Tang TK . The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation . Blood . 92 . 4 . 1442–7 . 1998 . 9694734 . 10.1182/blood.V92.4.1442.
• Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE . pICln inhibits snRNP biogenesis by binding core spliceosomal proteins . Mol. Cell. Biol. . 19 . 6 . 4113–20 . 1999 . 10330151 . 104370 . 10.1128/MCB.19.6.4113.
• Hubert MD, Levitan I, Hoffman MM, Zraggen M, Hofreiter ME, Garber SS . Modulation of volume regulated anion current by I(Cln) . Biochim. Biophys. Acta . 1466 . 1–2 . 105–14 . 2000 . 10825435 . 10.1016/S0005-2736(00)00177-2 . free .
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G . The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins . Mol. Cell. Biol. . 21 . 24 . 8289–300 . 2001 . 11713266 . 99994 . 10.1128/MCB.21.24.8289-8300.2001 .
• Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U . Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln . Curr. Biol. . 11 . 24 . 1990–4 . 2002 . 11747828 . 10.1016/S0960-9822(01)00592-9 . 11858/00-001M-0000-0012-F501-7 . 14742376 . free .
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G . A novel WD repeat protein component of the methylosome binds Sm proteins . J. Biol. Chem. . 277 . 10 . 8243–7 . 2002 . 11756452 . 10.1074/jbc.M109984200 . free .
• Meyer G, Rodighiero S, Guizzardi F, Bazzini C, Bottà G, Bertocchi C, Garavaglia L, Dossena S, Manfredi R, Sironi C, Catania A, Paulmichl M . Volume-regulated Cl⁻ channels in human pleural mesothelioma cells . FEBS Lett. . 559 . 1–3 . 45–50 . 2004 . 14960305 . 10.1016/S0014-5793(04)00020-1 . 2004FEBSL.559...45M . 24747269 .
• Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N . ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation . J. Biol. Chem. . 279 . 26 . 27286–93 . 2004 . 15075326 . 10.1074/jbc.M402159200 . free .
• Fürst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M . ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4 . J. Biol. Chem. . 280 . 35 . 31276–82 . 2005 . 15905169 . 10.1074/jbc.M500541200 . free .
• Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D . Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes . J. Biol. Chem. . 280 . 41 . 34435–40 . 2005 . 16087681 . 10.1074/jbc.M505077200 . free . 21.11116/0000-0007-E5F1-6 . free .

Notes and References

1. Anguita J, Chalfant ML, Civan MM, Coca-Prados M . Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium . Biochem Biophys Res Commun . 208 . 1 . 89–95 . Apr 1995 . 7887970 . 10.1006/bbrc.1995.1309 .
2. Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M . Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln . Genomics . 38 . 3 . 438–41 . Mar 1997 . 8975725 . 10.1006/geno.1996.0651 .
3. Web site: Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A.
4. Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N . ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation . J. Biol. Chem. . 279 . 26 . 27286–93 . Jun 2004 . 15075326 . 10.1074/jbc.M402159200 . free .
5. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE . pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology . J. Biol. Chem. . 273 . 18 . 10811–4 . May 1998 . 9556550 . 10.1074/jbc.273.18.10811. free .
6. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G . A novel WD repeat protein component of the methylosome binds Sm proteins . J. Biol. Chem. . 277 . 10 . 8243–7 . Mar 2002 . 11756452 . 10.1074/jbc.M109984200 . free .
7. Krzyzanowski A, Gasper R, Adihou H, 't Hart P, Waldmann H . Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex . ChemBioChem . Feb 2021 . 22 . 11 . 1908–1914 . 10.1002/cbic.202100079 . 33624332 . 8252068 . free .
8. Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G . The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins . Mol. Cell. Biol. . 21 . 24 . 8289–300 . Dec 2001 . 11713266 . 99994 . 10.1128/MCB.21.24.8289-8300.2001 .