CLK2 explained

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.^[4]

Further reading

• Lee K, Du C, Horn M, Rabinow L . Activity and autophosphorylation of LAMMER protein kinases . The Journal of Biological Chemistry . 271 . 44 . 27299–303 . Nov 1996 . 8910305 . 10.1074/jbc.271.44.27299 . free .
• Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E . Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease . Genome Research . 7 . 10 . 1020–6 . Oct 1997 . 9331372 . 310674 . 10.1101/gr.7.10.1020 .
• Duncan PI, Stojdl DF, Marius RM, Scheit KH, Bell JC . The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing . Experimental Cell Research . 241 . 2 . 300–8 . Jun 1998 . 9637771 . 10.1006/excr.1998.4083 .
• Tsujikawa M, Kurahashi H, Tanaka T, Okada M, Yamamoto S, Maeda N, Watanabe H, Inoue Y, Kiridoshi A, Matsumoto K, Ohashi Y, Kinoshita S, Shimomura Y, Nakamura Y, Tano Y . Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p . American Journal of Human Genetics . 63 . 4 . 1073–7 . Oct 1998 . 9758629 . 1377503 . 10.1086/302071 .
• Nayler O, Schnorrer F, Stamm S, Ullrich A . The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation . The Journal of Biological Chemistry . 273 . 51 . 34341–8 . Dec 1998 . 9852100 . 10.1074/jbc.273.51.34341 . free .
• Moeslein FM, Myers MP, Landreth GE . The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B . The Journal of Biological Chemistry . 274 . 38 . 26697–704 . Sep 1999 . 10480872 . 10.1074/jbc.274.38.26697 . free .
• Nothwang HG, Kim HG, Aoki J, Geisterfer M, Kübart S, Wegner RD, van Moers A, Ashworth LK, Haaf T, Bell J, Arai H, Tommerup N, Ropers HH, Wirth J . Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain . Human Molecular Genetics . 10 . 8 . 797–806 . Apr 2001 . 11285245 . 10.1093/hmg/10.8.797 . free .
• Ravichandran LV, Chen H, Li Y, Quon MJ . Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor . Molecular Endocrinology . 15 . 10 . 1768–80 . Oct 2001 . 11579209 . 10.1210/mend.15.10.0711 . free .
• Jiang N, Bénard CY, Kébir H, Shoubridge EA, Hekimi S . Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation . The Journal of Biological Chemistry . 278 . 24 . 21678–84 . Jun 2003 . 12670948 . 10.1074/jbc.M300286200 . free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biology . 5 . 2 . R8 . 2005 . 14759258 . 395752 . 10.1186/gb-2004-5-2-r8 . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2004CBio...14.1436J . 2371325 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ . HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability . Nature Cell Biology . 9 . 4 . 391–401 . Apr 2007 . 17384638 . 10.1038/ncb1555 . 544104 .

Notes and References

1. Hanes J, von der Kammer H, Klaudiny J, Scheit KH . Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases . Journal of Molecular Biology . 244 . 5 . 665–72 . Dec 1994 . 7990150 . 10.1006/jmbi.1994.1763 .
2. Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L . Chromosomal mapping of three human LAMMER protein-kinase-encoding genes . Human Genetics . 103 . 4 . 523–4 . Oct 1998 . 9856501 . 10.1007/s004390050861 . 40593571 .
3. Web site: Entrez Gene: CLK2 CDC-like kinase 2.
4. Web site: Entrez Gene: CLK2 CDC-like kinase 2.