CLEC2D explained

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.^[1]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.^[1] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene.In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

Further reading

• Boles KS, Barten R, Kumaresan PR . Cloning of a new lectin-like receptor expressed on human NK cells. . Immunogenetics . 50 . 1–2 . 1–7 . 1999 . 10541800 . 10.1007/s002510050679 . 30994521 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. free . 2002PNAS...9916899M .
• Iizuka K, Naidenko OV, Plougastel BF . Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors . Nat. Immunol. . 4 . 8 . 801–7 . 2003 . 12858173 . 10.1038/ni954 . 23775959 . etal.
• Hu YS, Zhou H, Myers D . Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts . J. Bone Miner. Res. . 19 . 1 . 89–99 . 2004 . 14753741 . 10.1359/JBMR.0301215 . 28328386 . etal. free .
• Carlyle JR, Jamieson AM, Gasser S . Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors . Proc. Natl. Acad. Sci. U.S.A. . 101 . 10 . 3527–32 . 2004 . 14990792 . 10.1073/pnas.0308304101 . 373496 . 2004PNAS..101.3527C . etal. free .
• Mathew PA, Chuang SS, Vaidya SV . The LLT1 receptor induces IFN-gamma production by human natural killer cells . Mol. Immunol. . 40 . 16 . 1157–63 . 2004 . 15104121 . 10.1016/j.molimm.2003.11.024 . etal.
• Gange CT, Quinn JM, Zhou H . Characterization of sugar binding by osteoclast inhibitory lectin . J. Biol. Chem. . 279 . 28 . 29043–9 . 2004 . 15123656 . 10.1074/jbc.M312518200 . etal. free .
• Aldemir H, Prod'homme V, Dumaurier MJ . Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor . J. Immunol. . 175 . 12 . 7791–5 . 2006 . 16339512 . 10.4049/jimmunol.175.12.7791. etal. free .
• Rosen DB, Bettadapura J, Alsharifi M . Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor . J. Immunol. . 175 . 12 . 7796–9 . 2006 . 16339513 . 10.4049/jimmunol.175.12.7796. etal. free .
• Rosen DB, Cao W . Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells . J. Immunol. . 180 . 10 . 6508–6517 . 2008 . 18453569 . 10.4049/jimmunol.180.10.6508. 2577150 . etal.

Notes and References

1. Web site: Entrez Gene: CLEC2D C-type lectin domain family 2, member D.