CLEC2B explained

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.^{[1] [2]}

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Further reading

• Drickamer K . C-type lectin-like domains . Curr. Opin. Struct. Biol. . 9 . 5 . 585–90 . 1999 . 10508765 . 10.1016/S0959-440X(99)00009-3 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ebner S, Sharon N, Ben-Tal N . Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily . Proteins . 53 . 1 . 44–55 . 2003 . 12945048 . 10.1002/prot.10440 . 30955198 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Renedo M . A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2 . Genomics . 65 . 2 . 129–36 . 2000 . 10783260 . 10.1006/geno.2000.6163 . vanc. Arce I . Montgomery K . 3 . Roda-Navarro . Pedro . Lee . Eunice . Kucherlapati . Raju . Fernández-Ruiz . Elena .
• Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S . Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank . Gene . 228 . 1–2 . 161–7 . 1999 . 10072769 . 10.1016/S0378-1119(99)00004-9 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA . AICL: a new activation-induced antigen encoded by the human NK gene complex . Immunogenetics . 45 . 5 . 295–300 . Mar 1997 . 9038101 . 10.1007/s002510050208 . 34214844 .
2. Web site: Entrez Gene: CLEC2B C-type lectin domain family 2, member B.