CLEC1B explained

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.^{[1] [2] [3]}

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Suzuki-Inoue K, Fuller GL, García A . A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 . Blood . 107 . 2 . 542–9 . 2006 . 16174766 . 10.1182/blood-2005-05-1994 . 168505 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Watson AA, O'Callaghan CA . Crystallization and X-ray diffraction analysis of human CLEC-2 . Acta Crystallographica Section F . 61 . Pt 12 . 1094–6 . 2006 . 16511244 . 10.1107/S1744309105037991 . 1978148 .
• Scherer SE, Muzny DM, Buhay CJ . The finished DNA sequence of human chromosome 12 . Nature . 440 . 7082 . 346–51 . 2006 . 16541075 . 10.1038/nature04569 . 2006Natur.440..346S . etal. free .
• Chaipan C, Soilleux EJ, Simpson P . DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets . J. Virol. . 80 . 18 . 8951–60 . 2006 . 16940507 . 10.1128/JVI.00136-06 . 1563896 . etal.
• Watson AA, Brown J, Harlos K . The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2 . J. Biol. Chem. . 282 . 5 . 3165–72 . 2007 . 17132623 . 10.1074/jbc.M610383200 . etal. free .
• Suzuki-Inoue K, Kato Y, Inoue O . Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells . J. Biol. Chem. . 282 . 36 . 25993–6001 . 2007 . 17616532 . 10.1074/jbc.M702327200 . etal. free .
• Watson AA, Eble JA, O'Callaghan CA . Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2. Protein Science . 17. 9. 1611–6. 2008 . 18583525 . 10.1110/ps.035568.108 . 2525532.

Notes and References

1. Colonna M, Samaridis J, Angman L . Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells . Eur J Immunol . 30 . 2 . 697–704 . Mar 2000 . 10671229 . 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . free .
2. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E . A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex . Eur J Immunol . 31 . 12 . 3493–503 . Dec 2001 . 11745369 . 10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 . 42415487 .
3. Web site: Entrez Gene: CLEC1B C-type lectin domain family 1, member B.