CLEC1A explained

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.^{[1] [2] [3]}

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[3]

Further reading

• Drickamer K . C-type lectin-like domains. . Curr. Opin. Struct. Biol. . 9 . 5 . 585–90 . 1999 . 10508765 . 10.1016/S0959-440X(99)00009-3 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ebner S, Sharon N, Ben-Tal N . Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. . Proteins . 53 . 1 . 44–55 . 2003 . 12945048 . 10.1002/prot.10440 . 30955198 .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .

Notes and References

1. Colonna M, Samaridis J, Angman L . Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells . Eur J Immunol . 30 . 2 . 697–704 . Mar 2000 . 10671229 . 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . free .
2. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E . A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex . Eur J Immunol . 31 . 12 . 3493–503 . Dec 2001 . 11745369 . 10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 . 42415487 .
3. Web site: Entrez Gene: CLEC1A C-type lectin domain family 1, member A.