CLDN8 explained

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene.^{[1] [2]} It belongs to the group of claudins.

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood–brain barrier . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2003 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Itoh M, Furuse M, Morita K . Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins . J. Cell Biol. . 147 . 6 . 1351–63 . 2000 . 10601346 . 10.1083/jcb.147.6.1351 . 2168087 . etal.
• Hattori M, Fujiyama A, Taylor TD . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . etal. free .
• Brandner JM, Kief S, Grund C . Organization and formation of the tight junction system in human epidermis and cultured keratinocytes . Eur. J. Cell Biol. . 81 . 5 . 253–63 . 2003 . 12067061 . 10.1078/0171-9335-00244 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Katoh M, Katoh M . CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family . Int. J. Mol. Med. . 11 . 6 . 683–9 . 2004 . 12736707 . 10.3892/ijmm.11.6.683.
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res. 2015 . 15 . 2 . 339–359 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Morita K, Furuse M, Fujimoto K, Tsukita S . Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands . Proc Natl Acad Sci U S A . 96 . 2 . 511–6 . Mar 1999 . 9892664 . 15167 . 10.1073/pnas.96.2.511 . 1999PNAS...96..511M . free .
2. Web site: Entrez Gene: CLDN8 claudin 8.