CLDN7 explained

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.^{[1] [2]} It belongs to the group of claudins.

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM]

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood–brain barrier . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2003 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Peacock RE, Keen TJ, Inglehearn CF . Analysis of a human gene homologous to rat ventral prostate.1 protein . Genomics . 46 . 3 . 443–9 . 1998 . 9441748 . 10.1006/geno.1997.5033 .
• Itoh M . Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins . J. Cell Biol. . 147 . 6 . 1351–63 . 2000 . 10601346 . 10.1083/jcb.147.6.1351 . 2168087 . Furuse M . Morita K . 3 . Kubota . K . Saitou . M . Tsukita . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kominsky SL . Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast . Oncogene . 22 . 13 . 2021–33 . 2003 . 12673207 . 10.1038/sj.onc.1206199 . Argani P . Korz D . 3 . Evron . Ella . Raman . Venu . Garrett . Elizabeth . Rein . Alan . Sauter . Guido . Kallioniemi . Olli-P . 20318884 .
• Ban Y . Tight junction-related protein expression and distribution in human corneal epithelium . Exp. Eye Res. . 76 . 6 . 663–9 . 2003 . 12742348 . 10.1016/S0014-4835(03)00054-X . Dota A . Cooper LJ . 3 . Fullwood . Nigel J. . Nakamura . Takahiro . Tsuzuki . Masakatsu . Mochida . Chikako . Kinoshita . Shigeru .
• Zheng JY . Regulation of the expression of the prostate-specific antigen by claudin-7 . J. Membr. Biol. . 194 . 3 . 187–97 . 2004 . 14502431 . 10.1007/s00232-003-2038-4 . Yu D . Foroohar M . 3 . Ko . E. . Chan . J. . Kim . N. . Chiu . R. . Pang . S. . 8482475 .
• Resnick MB . Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study . Mod. Pathol. . 18 . 4 . 511–8 . 2005 . 15475928 . 10.1038/modpathol.3800301 . Konkin T . Routhier J . 3 . Sabo . Edmond . Pricolo . Victor E . 28512983 .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res . 2015 . 15 . 2 . 339–359 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Morita K, Furuse M, Fujimoto K, Tsukita S . Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands . Proc Natl Acad Sci U S A . 96 . 2 . 511–6 . Mar 1999 . 9892664 . 15167 . 10.1073/pnas.96.2.511 . 1999PNAS...96..511M . free .
2. Web site: Entrez Gene: CLDN7 claudin 7.