CLDN5 explained

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.^{[1] [2] [3]} It belongs to the group of claudins.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.

Interactions

CLDN5 has been shown to interact with CLDN1^[4] and CLDN3.^[4]

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood-brain barrier . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2002 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• King JE, Eugenin EA, Buckner CM, Berman JW . HIV tat and neurotoxicity . Microbes Infect. . 8 . 5 . 1347–57 . 2006 . 16697675 . 10.1016/j.micinf.2005.11.014 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Morita K, Furuse M, Fujimoto K, Tsukita S . Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands . Proc. Natl. Acad. Sci. U.S.A. . 96 . 2 . 511–6 . 1999 . 9892664 . 15167 . 10.1073/pnas.96.2.511 . 1999PNAS...96..511M . free .
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S . Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins . J. Cell Biol. . 147 . 6 . 1351–63 . 1999 . 10601346 . 2168087 . 10.1083/jcb.147.6.1351 .
• Kojima S, Rahner C, Peng S, Rizzolo LJ . Claudin 5 is transiently expressed during the development of the retinal pigment epithelium . J. Membr. Biol. . 186 . 2 . 81–8 . 2002 . 11944085 . 10.1007/s00232-001-0137-7 . 13468318 .
• Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E . Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells . J. Cell Biol. . 159 . 2 . 361–72 . 2002 . 12403818 . 2173042 . 10.1083/jcb.200207050 .
• Helms HC, Waagepetersen HS, Nielsen CU, Brodin B . Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth . AAPS J . 12 . 4 . 759–70 . 2010 . 20967520 . 2976989 . 10.1208/s12248-010-9237-6 .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res . 2015 . 15 . 2 . 339–359 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Peacock RE, Keen TJ, Inglehearn CF . Analysis of a human gene homologous to rat ventral prostate.1 protein . Genomics . 46 . 3 . 443–9 . December 1997 . 9441748 . 10.1006/geno.1997.5033 .
2. Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R . Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome . Genomics . 42 . 2 . 245–51 . Sep 1997 . 9192844 . 10.1006/geno.1997.4734 . free .
3. Web site: Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome).
4. Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG . Role of claudin interactions in airway tight junctional permeability . Am. J. Physiol. Lung Cell Mol. Physiol. . 285 . 5 . L1166-78 . Nov 2003 . 12909588 . 10.1152/ajplung.00182.2003 .