CLDN17 explained

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^{[1] [2]} It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[3] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^{[4] [5]}

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins. . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets. . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2003 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions. . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport. . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Kniesel U, Wolburg H . Tight junctions of the blood–brain barrier. . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Hu YH, Warnatz HJ, Vanhecke D . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . etal . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Brandner JM, Kief S, Grund C . Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. . Eur. J. Cell Biol. . 81 . 5 . 253–63 . 2003 . 12067061 . 10.1078/0171-9335-00244 . etal.
• Hattori M, Fujiyama A, Taylor TD . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . etal. free .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res . 2015 . 15 . 2 . 339–359 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Katoh M, Katoh M . CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family . Int J Mol Med . 11 . 6 . 683–9 . May 2003 . 12736707 . 10.3892/ijmm.11.6.683.
2. Web site: Entrez Gene: CLDN17 claudin 17.
3. Adil . MS . Narayanan . SP . Somanath . PR . Cell-cell junctions: structure and regulation in physiology and pathology. . Tissue Barriers . 2021 . 9 . 1 . 1848212 . 10.1080/21688370.2020.1848212 . 33300427 . 7849786 . 5.
4. Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M . Claudin-17 forms tight junction channels with distinct anion selectivity . Cell Mol Life Sci . 69 . 16 . 2765–78 . 2012 . 22402829 . 10.1007/s00018-012-0949-x. 18173604 . 11115135 .
5. Adil . M . Parvathagiri . V . Verma . A . Liu . F . Rudraraju . M . Narayanan . SP . Somanath . PR . Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress . Cells . 2022 . 11 . 11 . 1782 . 10.3390/cells11111782 . 35681477 . 9180152 . 4. free .