CLDN15 explained

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene.^[1] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.^[2]

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood–brain barrier. . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport. . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . 12132159 .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions. . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets. . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2003 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins. . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 .
• Yi X, Wang Y, Yu FS . Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. . Invest. Ophthalmol. Vis. Sci. . 41 . 13 . 4093–100 . 2000 . 11095601 .
• Kiuchi-Saishin Y, Gotoh S, Furuse M . Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. . J. Am. Soc. Nephrol. . 13 . 4 . 875–86 . 2002 . 10.1681/ASN.V134875 . 11912246 . etal. free .
• Colegio OR, Van Itallie CM, McCrea HJ . Claudins create charge-selective channels in the paracellular pathway between epithelial cells. . Am. J. Physiol., Cell Physiol. . 283 . 1 . C142–7 . 2002 . 12055082 . 10.1152/ajpcell.00038.2002 . 9555118 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Van Itallie CM, Fanning AS, Anderson JM . Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. . Am. J. Physiol. Renal Physiol. . 285 . 6 . F1078–84 . 2003 . 13129853 . 10.1152/ajprenal.00116.2003 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res . 2015 . 15 . 2 . 339–359 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Web site: Entrez Gene: CLDN15 claudin 15.
2. Web site: CLDN15 Gene - GeneCards CLD15 Protein CLD15 Antibody. Database. GeneCards Human Gene. www.genecards.org. 2017-04-14.