CLCN6 explained

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.^[1]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.^[2]

See also

• Chloride channel

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Nomura N, Nagase T, Miyajima N . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. . DNA Res. . 1 . 5 . 223–9 . 1995 . 7584044 . 10.1093/dnares/1.5.223 . etal. free .
• Eggermont J, Buyse G, Voets T . Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific . Biochem. J. . 325 . Pt 1. 269–76 . 1997 . 9224655 . 10.1042/bj3250269. 1218554 . etal.
• Eggermont J . The exon-intron architecture of human chloride channel genes is not conserved . Biochim. Biophys. Acta . 1397 . 2 . 156–60 . 1998 . 9565675 . 10.1016/s0167-4781(98)00014-1.
• Lamb FS, Clayton GH, Liu BX . Expression of CLCN voltage-gated chloride channel genes in human blood vessels . J. Mol. Cell. Cardiol. . 31 . 3 . 657–66 . 1999 . 10198195 . 10.1006/jmcc.1998.0901 . etal.
• Kornak U, Bösl MR, Kubisch C . Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1) . Biochim. Biophys. Acta . 1447 . 1 . 100–6 . 1999 . 10500249 . 10.1016/s0167-4781(99)00128-1.
• Lamb FS, Graeff RW, Clayton GH . Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium . Am. J. Respir. Cell Mol. Biol. . 24 . 4 . 376–81 . 2001 . 11306429 . 10.1165/ajrcmb.24.4.4114. etal.
• Tran P, Leclerc D, Chan M . Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms . Mamm. Genome . 13 . 9 . 483–92 . 2003 . 12370778 . 10.1007/s00335-002-2167-6 . 19722541 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . etal. 2006Natur.441..315G . free .

Notes and References

1. Brandt S, Jentsch TJ . ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family . FEBS Lett . 377 . 1 . 15–20 . Feb 1996 . 8543009 . 10.1016/0014-5793(95)01298-2 . 717696 .
2. Web site: Entrez Gene: CLCN6 chloride channel 6.