CLASP2 explained

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.^[1]

Further reading

• Galjart N . CLIPs and CLASPs and cellular dynamics. . Nat. Rev. Mol. Cell Biol. . 6 . 6 . 487–98 . 2005 . 15928712 . 10.1038/nrm1664 . 23216754 .
• Ishikawa K, Nagase T, Suyama M . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 3 . 169–76 . 1998 . 9734811 . 10.1093/dnares/5.3.169 . etal. free .
• Lemos CL, Sampaio P, Maiato H . Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. . EMBO J. . 19 . 14 . 3668–82 . 2000 . 10899121 . 10.1093/emboj/19.14.3668 . 313969 . etal.
• Casper Hoogenraad . Akhmanova A, Hoogenraad CC, Drabek K . Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. . Cell . 104 . 6 . 923–35 . 2001 . 11290329 . 10.1016/S0092-8674(01)00288-4 . 14443149 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Maiato H, Fairley EA, Rieder CL . Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. . Cell . 113 . 7 . 891–904 . 2003 . 12837247 . 10.1016/S0092-8674(03)00465-3 . etal. 10216/53832 . 13936836 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Lee H, Engel U, Rusch J . The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. . Neuron . 42 . 6 . 913–26 . 2004 . 15207236 . 10.1016/j.neuron.2004.05.020 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G . CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. . J. Cell Biol. . 168 . 1 . 141–53 . 2005 . 15631994 . 10.1083/jcb.200405094 . 2171674 . etal.
• Wittmann T, Waterman-Storer CM . Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. . J. Cell Biol. . 169 . 6 . 929–39 . 2005 . 15955847 . 10.1083/jcb.200412114 . 2171640 .
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y . CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. . Dev. Cell . 11 . 1 . 21–32 . 2006 . 16824950 . 10.1016/j.devcel.2006.05.012 . etal. free .
• Mimori-Kiyosue Y, Grigoriev I, Sasaki H . Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. . Genes Cells . 11 . 8 . 845–57 . 2006 . 16866869 . 10.1111/j.1365-2443.2006.00990.x . 33744175 . etal. free .
• Pereira AL, Pereira AJ, Maia AR . Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. . Mol. Biol. Cell . 17 . 10 . 4526–42 . 2007 . 16914514 . 10.1091/mbc.E06-07-0579 . 1635371 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Web site: Entrez Gene: CLASP2 cytoplasmic linker associated protein 2.