Collectin-12 Explained

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.^[1]

Function

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].

Further reading

• Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y, Wakamiya N, Hata A . Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene . J. Hum. Genet. . 48 . 2 . 82–5 . 2003 . 12601552 . 10.1007/s100380300011 . free .
• Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R . SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen . J. Biochem. . 133 . 3 . 271–7 . March 2003 . 12761161 . 10.1093/jb/mvg037 .
• Coombs PJ, Graham SA, Drickamer K, Taylor ME . Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands . J. Biol. Chem. . 280 . 24 . 22993–9 . June 2005 . 15845541 . 10.1074/jbc.M504197200 . free . 11858/00-001M-0000-0011-5639-F . free .
• Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S . Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues . Mol. Immunol. . 45 . 11 . 3278–88 . June 2008 . 18423602 . 10.1016/j.molimm.2008.02.018 .
• Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N . Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells . J. Biol. Chem. . 284 . 6 . 3956–65 . February 2009 . 19073604 . 10.1074/jbc.M807477200 . free .
• Samsen A, Bogoevska V, Klampe B, Bamberger AM, Lucka L, Horst AK, Nollau P, Wagener C . DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools . Eur. J. Cell Biol. . 89 . 1 . 87–94 . January 2010 . 20034698 . 10.1016/j.ejcb.2009.11.018 .
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M . New genetic associations detected in a host response study to hepatitis B vaccine . Genes Immun. . 11 . 3 . 232–8 . April 2010 . 20237496 . 10.1038/gene.2010.1 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Graham SA, Antonopoulos A, Hitchen PG, Haslam SM, Dell A, Drickamer K, Taylor ME . Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin . J. Biol. Chem. . 286 . 27 . 24336–49 . July 2011 . 21561871 . 3129213 . 10.1074/jbc.M111.244772 . free .

Notes and References

1. Web site: Entrez Gene: Collectin subfamily member 12. 2019-12-24.