CKS2 explained

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.^{[1] [2] [3]}

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.

Further reading

• Parge HE, Arvai AS, Murtari DJ . Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. . Science . 262 . 5132 . 387–95 . 1993 . 8211159 . 10.1126/science.8211159 . 1993Sci...262..387P . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Le XF, Lammayot A, Gold D . Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. . J. Biol. Chem. . 280 . 3 . 2092–104 . 2005 . 15504738 . 10.1074/jbc.M403080200 . etal. free .
• Gorr IH, Boos D, Stemmann O . Mutual inhibition of separase and Cdk1 by two-step complex formation. . Mol. Cell . 19 . 1 . 135–41 . 2005 . 15989971 . 10.1016/j.molcel.2005.05.022 . free .
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Rother K, Dengl M, Lorenz J . Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73. . FEBS Lett. . 581 . 6 . 1166–72 . 2007 . 17336302 . 10.1016/j.febslet.2007.02.028 . 6953397 . etal. free .
• Bertheau P, Turpin E, Rickman DS . Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. . PLOS Med. . 4 . 3 . e90 . 2007 . 17388661 . 10.1371/journal.pmed.0040090 . 1831731 . etal . free .

Notes and References

1. Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI . Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe . Genes Dev . 4 . 8 . 1332–44 . Dec 1990 . 2227411 . 10.1101/gad.4.8.1332 . free .
2. Demetrick DJ, Zhang H, Beach DH . Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22 . Cytogenet Cell Genet . 73 . 3 . 250–4 . Sep 1996 . 8697818 . 10.1159/000134349 .
3. Web site: Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2.