CJ-033466 explained
CJ-033466 is a drug which acts as a potent and selective 5-HT4 serotonin receptor partial agonist. In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the hERG channel.[1] [2] [3]
See also
Notes and References
- Mikami T, Ochi Y, Suzuki K, Saito T, Sugie Y, Sakakibara M . 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs . The Journal of Pharmacology and Experimental Therapeutics . 325 . 1 . 190–9 . April 2008 . 18198343 . 10.1124/jpet.107.133850 . 40500864 .
- Toga T, Kohmura Y, Kawatsu R . The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities . Journal of Pharmacological Sciences . 105 . 2 . 207–10 . October 2007 . 17928736 . 10.1254/jphs.sc0070243. free .
- Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, Hori M, Ozaki H . Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus . Gut . 60 . 5 . 638–47 . May 2011 . 21115544 . 3071096 . 10.1136/gut.2010.227546 .
