CITED2 explained

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.^{[1] [2] [3]}

Interactions

CITED2 has been shown to interact with EP300,^{[4] [5] [6] [7]} LHX2,^[7] TFAP2A,^{[5] [6]} and WT1.^[8]

Further reading

• Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS . CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor . The Journal of Endocrinology . 192 . 2 . 459–65 . Feb 2007 . 17283246 . 10.1677/JOE-06-0083 . free .
• Shioda T, Fenner MH, Isselbacher KJ . MSG1 and its related protein MRG1 share a transcription activating domain . Gene . 204 . 1–2 . 235–41 . Dec 1997 . 9434189 . 10.1016/S0378-1119(97)00551-9 .
• Sun HB, Zhu YX, Yin T, Sledge G, Yang YC . MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity . Proceedings of the National Academy of Sciences of the United States of America . 95 . 23 . 13555–60 . Nov 1998 . 9811838 . 24857 . 10.1073/pnas.95.23.13555 . 1998PNAS...9513555S . free .
• Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM . Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 . Genes & Development . 13 . 1 . 64–75 . Jan 1999 . 9887100 . 316375 . 10.1101/gad.13.1.64 .
• Glenn DJ, Maurer RA . MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression . The Journal of Biological Chemistry . 274 . 51 . 36159–67 . Dec 1999 . 10593900 . 10.1074/jbc.274.51.36159 . free .
• Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S . Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 . The Journal of Biological Chemistry . 277 . 10 . 8559–65 . Mar 2002 . 11744733 . 10.1074/jbc.M110850200 . free .
• Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S . Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 . The Journal of Biological Chemistry . 278 . 18 . 16021–9 . May 2003 . 12586840 . 10.1074/jbc.M208144200 . free .
• Liu L, Amy V, Liu G, McKeehan WL . Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells . In Vitro Cellular & Developmental Biology. Animal . 38 . 10 . 582–94 . 2003 . 12762840 . 3225227 . 10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2 .
• Yokota H, Goldring MB, Sun HB . CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear . The Journal of Biological Chemistry . 278 . 47 . 47275–80 . Nov 2003 . 12960175 . 10.1074/jbc.M304652200 . free .
• Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S . Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene . The EMBO Journal . 22 . 23 . 6299–309 . Dec 2003 . 14633989 . 291836 . 10.1093/emboj/cdg595 .
• Tien ES, Davis JW, Vanden Heuvel JP . Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator . The Journal of Biological Chemistry . 279 . 23 . 24053–63 . Jun 2004 . 15051727 . 10.1074/jbc.M401489200 . free .
• Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S . Identification and functional analysis of CITED2 mutations in patients with congenital heart defects . Human Mutation . 26 . 6 . 575–82 . Dec 2005 . 16287139 . 10.1002/humu.20262 . 24646760 . 11858/00-001M-0000-0010-8560-F . free .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mammalian Genome . 16 . 12 . 942–54 . Dec 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Chou YT, Yang YC . Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region . The Journal of Biological Chemistry . 281 . 27 . 18451–62 . Jul 2006 . 16675452 . 10.1074/jbc.M601720200 . free .
• Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC . Cited2, a coactivator of HNF4alpha, is essential for liver development . The EMBO Journal . 26 . 21 . 4445–56 . Oct 2007 . 17932483 . 2063472 . 10.1038/sj.emboj.7601883 .

Notes and References

1. Shioda T, Fenner MH, Isselbacher KJ . msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation . Proceedings of the National Academy of Sciences of the United States of America . 93 . 22 . 12298–303 . Oct 1996 . 8901575 . 37985 . 10.1073/pnas.93.22.12298 . 1996PNAS...9312298S . free .
2. Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S . Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1 . Genomics . 61 . 3 . 307–13 . Nov 1999 . 10552932 . 10.1006/geno.1999.5970 .
3. Web site: Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2.
4. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM . Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 . Genes & Development . 13 . 1 . 64–75 . Jan 1999 . 9887100 . 316375 . 10.1101/gad.13.1.64 .
5. Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S . Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 . The Journal of Biological Chemistry . 278 . 18 . 16021–9 . May 2003 . 12586840 . 10.1074/jbc.M208144200 . free .
6. Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S . Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 . The Journal of Biological Chemistry . 277 . 10 . 8559–65 . Mar 2002 . 11744733 . 10.1074/jbc.M110850200 . free .
7. Glenn DJ, Maurer RA . MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression . The Journal of Biological Chemistry . 274 . 51 . 36159–67 . Dec 1999 . 10593900 . 10.1074/jbc.274.51.36159 . free .
8. Val P, Martinez-Barbera JP, Swain A . Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage . Development . 134 . 12 . 2349–58 . Jun 2007 . 17537799 . 10.1242/dev.004390 . free .