CISD2 explained

CDGSH iron sulfur domain 2 is a protein that in humans is encoded by the CISD2 gene.^[1]

Function

The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011].

See also

• CDGSH iron sulfur domain

Further reading

• Shu SG, Tsai CR, Chi CS . Wolfram syndrome: phenotype and novel mutation in two Taiwanese siblings . J. Formos. Med. Assoc. . 102 . 11 . 808–11 . November 2003 . 14724730 .
• Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H, Shiang R . A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2 . Am. J. Hum. Genet. . 81 . 4 . 673–83 . October 2007 . 17846994 . 2227919 . 10.1086/520961 .
• Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML . Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2 . J. Mol. Biol. . 392 . 1 . 143–53 . September 2009 . 19580816 . 2739586 . 10.1016/j.jmb.2009.06.079 .
• Chang NC, Nguyen M, Germain M, Shore GC . Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 . EMBO J. . 29 . 3 . 606–18 . February 2010 . 20010695 . 2830692 . 10.1038/emboj.2009.369 .
• Chen YF, Wu CY, Kirby R, Kao CH, Tsai TF . A role for the CISD2 gene in lifespan control and human disease . Ann. N. Y. Acad. Sci. . 1201 . 58–64 . July 2010 . 1 . 20649540 . 10.1111/j.1749-6632.2010.05619.x . 2010NYASA1201...58C . 22176942 .
• Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R . Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs . PLOS ONE . 8 . 5 . e61202 . 2013 . 23717386 . 3661554 . 10.1371/journal.pone.0061202 . 2013PLoSO...861202T . free .
• Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R . NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth . Proc. Natl. Acad. Sci. U.S.A. . 110 . 36 . 14676–81 . September 2013 . 23959881 . 3767537 . 10.1073/pnas.1313198110 . 2013PNAS..11014676S . free .
• Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R . Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1 . Proc. Natl. Acad. Sci. U.S.A. . 111 . 14 . 5177–82 . April 2014 . 24706857 . 3986192 . 10.1073/pnas.1403770111 . 2014PNAS..111.5177T . free .
• Liu L, Xia M, Wang J, Zhang W, Zhang Y, He M . CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer . Med. Oncol. . 31 . 9 . 183 . September 2014 . 25134919 . 10.1007/s12032-014-0183-5 . 40242445 .

External links

• CISD2

Notes and References

1. Web site: CISD2 CDGSH iron sulfur domain 2 [Homo sapiens (human) ]]. National Center for Biotechnology Information. 2018-06-04.