CHTF18 explained

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.^{[1] [2]}

Interactions

CHTF18 has been shown to interact with:

• DCC1,^{[3] [4]}
• PCNA,
• RFC2,^{[3] [4]}
• RFC3,^{[3] [4]}
• RFC4,^[3] and
• RFC5.^[3]

Further reading

• Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T . A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity . The Journal of Biological Chemistry . 282 . 29 . 20906–14 . Jul 2007 . 17545166 . 10.1074/jbc.M610102200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J . The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA . Proceedings of the National Academy of Sciences of the United States of America . 100 . 18 . 10237–42 . Sep 2003 . 12930902 . 193545 . 10.1073/pnas.1434308100 . 2003PNAS..10010237B . free .
• Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J . Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment . The Journal of Biological Chemistry . 278 . 32 . 30051–6 . Aug 2003 . 12766176 . 10.1074/jbc.M211591200 . free .
• Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K . Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway . Molecular and Cellular Biology . 21 . 17 . 5838–45 . Sep 2001 . 11486023 . 87303 . 10.1128/MCB.21.17.5838-5845.2001 .
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Human Molecular Genetics . 10 . 4 . 339–52 . Feb 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .

Notes and References

1. Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . The Journal of Biological Chemistry . 277 . 43 . 40362–7 . Oct 2002 . 12171929 . 10.1074/jbc.M206194200 . free .
2. Web site: Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae).
3. Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J . The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA . Proceedings of the National Academy of Sciences of the United States of America . 100 . 18 . 10237–42 . Sep 2003 . 12930902 . 193545 . 10.1073/pnas.1434308100 . 2003PNAS..10010237B . free .
4. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J . Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment . The Journal of Biological Chemistry . 278 . 32 . 30051–6 . Aug 2003 . 12766176 . 10.1074/jbc.M211591200 . free .