CHSY1 explained

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.^{[1] [2]}

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.^{[3] [4]}

Further reading

• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117. etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697. etal.
• Yada T, Sato T, Kaseyama H . Chondroitin sulfate synthase-3. Molecular cloning and characterization. . J. Biol. Chem. . 278 . 41 . 39711–25 . 2003 . 12907687 . 10.1074/jbc.M304421200. etal. free .
• Kitagawa H, Izumikawa T, Uyama T, Sugahara K . Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. . J. Biol. Chem. . 278 . 26 . 23666–71 . 2003 . 12716890 . 10.1074/jbc.M302493200. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Nagase T, Ishikawa K, Suyama M . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63. etal. free .

Notes and References

1. Kitagawa H, Uyama T, Sugahara K . Molecular cloning and expression of a human chondroitin synthase . J Biol Chem . 276 . 42 . 38721–6 . Oct 2001 . 11514575 . 10.1074/jbc.M106871200 . free .
2. Web site: Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1.
3. supplied by OMIM
4. Web site: Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1.