CHST11 explained

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.^{[1] [2]}

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.^[3]

Further reading

• Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O . Molecular cloning and expression of chondroitin 4-sulfotransferase . The Journal of Biological Chemistry . 275 . 12 . 8975–81 . Mar 2000 . 10722746 . 10.1074/jbc.275.12.8975 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3491–6 . Mar 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . 2000PNAS...97.3491D . free .
• Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O . Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase . Journal of Biochemistry . 128 . 5 . 763–70 . Nov 2000 . 11056388 . 10.1093/oxfordjournals.jbchem.a022813 .
• Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K . Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis . The Journal of Biological Chemistry . 278 . 38 . 36115–27 . Sep 2003 . 12847091 . 10.1074/jbc.M306044200 . free .
• Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS . Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32) . Oncogene . 23 . 41 . 6991–6 . Sep 2004 . 15273723 . 10.1038/sj.onc.1207934 . free .
• Yamada T, Ohtake S, Sato M, Habuchi O . Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues . The Biochemical Journal . 384 . Pt 3 . 567–75 . Dec 2004 . 15324304 . 1134142 . 10.1042/BJ20040965 .
• Yusa A, Kitajima K, Habuchi O . N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1 . The Biochemical Journal . 388 . Pt 1 . 115–21 . May 2005 . 15628971 . 1186699 . 10.1042/BJ20041573 .

Notes and References

1. Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M . Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family . The Journal of Biological Chemistry . 275 . 26 . 20188–96 . Jun 2000 . 10781601 . 10.1074/jbc.M002443200 . free .
2. Web site: Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11.
3. Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Laughlin J . 6 . Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study . Lancet . 380 . 9844 . 815–23 . Sep 2012 . 22763110 . 10.1016/S0140-6736(12)60681-3 . 3443899.