CHST10 explained

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.^{[1] [2]}

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM]

Further reading

• Kimura K . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ong E . Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis . J. Biol. Chem. . 274 . 36 . 25608–12 . 1999 . 10464296 . 10.1074/jbc.274.36.25608 . vanc. Yeh JC . Ding Y . 3 . Hindsgaul . O . Pedersen . LC . Negishi . M . Fukuda . M . free .
• Ong E . Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids . J. Biol. Chem. . 273 . 9 . 5190–5 . 1998 . 9478973 . 10.1074/jbc.273.9.5190 . vanc. Yeh JC . Ding Y . 3 . Hindsgaul . O . Fukuda . M . free.
• Yu W . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
• Shilatifard A . Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine . J. Virol. . 67 . 2 . 943–52 . 1993 . 8419650 . 10.1128/JVI.67.2.943-952.1993. 237448 . vanc. Merkle RK . Helland DE . 3 . Welles . JL . Haseltine . WA . Cummings . RD .
• Bernstein HB, Compans RW . Sulfation of the human immunodeficiency virus envelope glycoprotein . J. Virol. . 66 . 12 . 6953–9 . 1992 . 1433500 . 10.1128/JVI.66.12.6953-6959.1992. 240329 .

Notes and References

1. Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M . Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases . J Biol Chem . 277 . 38 . 34766–72 . Sep 2002 . 12080076 . 10.1074/jbc.M204907200 . free .
2. Web site: Entrez Gene: CHST10 carbohydrate sulfotransferase 10.