CHRNB3 explained

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.^{[1] [2]} This gene has been identified as a candidate for predisposition to tobacco dependence.

See also

• Nicotinic acetylcholine receptor

Further reading

• Green WN, Millar NS . Ion-channel assembly. . Trends Neurosci. . 18 . 6 . 280–7 . 1995 . 7571003 . 10.1016/0166-2236(95)93915-K .
• Book: Hogg RC, Raggenbass M, Bertrand D . Reviews of Physiology, Biochemistry and Pharmacology . Nicotinic acetylcholine receptors: from structure to brain function . Rev. Physiol. Biochem. Pharmacol. . 147 . 1–46 . 2003 . 12783266 . 10.1007/s10254-003-0005-1 . 978-3-540-01365-5 .
• Willoughby JJ . Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit . Neurosci. Lett. . 155 . 2 . 136–9 . 1993 . 7690916 . 10.1016/0304-3940(93)90691-D . vanc. Ninkina NN . Beech MM . 3 . Latchman . D . Wood . J . 39225391 .
• Koyama K, Sudo K, Nakamura Y . Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2 . Genomics . 21 . 2 . 460–1 . 1994 . 8088849 . 10.1006/geno.1994.1300 .
• Elliott KJ . Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits . J. Mol. Neurosci. . 7 . 3 . 217–28 . 1997 . 8906617 . 10.1007/BF02736842 . vanc. Ellis SB . Berckhan KJ . 3 . Urrutia . Arturo . Chavez-Noriega . Laura E. . Johnson . Edwin C. . Veliçelebi . Gönül . Harpold . Michael M. . 45737923 .
• Groot Kormelink PJ, Luyten WH . Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 . FEBS Lett. . 400 . 3 . 309–14 . 1997 . 9009220 . 10.1016/S0014-5793(96)01383-X . 82364119 .
• Navaneetham D, Penn A, Howard J, Conti-Fine BM . Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses . Cell. Mol. Biol. (Noisy-le-grand) . 43 . 3 . 433–42 . 1997 . 9193799 .
• Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG . A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor . J. Biol. Chem. . 273 . 25 . 15317–20 . 1998 . 9624109 . 10.1074/jbc.273.25.15317 . free .
• Sato KZ . Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines . Neurosci. Lett. . 266 . 1 . 17–20 . 1999 . 10336173 . 10.1016/S0304-3940(99)00259-1 . vanc. Fujii T . Watanabe Y . 3 . Yamada . Shin . Ando . Tsuyoshi . Kazuko . Fujimoto . Kawashima . Koichiro . 43548155 .
• Boorman JP, Groot-Kormelink PJ, Sivilotti LG . Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes . J. Physiol. . 529 Pt 3 . Pt 3. 565–77 . 2001 . 11118490 . 10.1111/j.1469-7793.2000.00565.x. 2270211 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Boorman JP . The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors . J. Biol. Chem. . 278 . 45 . 44033–40 . 2004 . 12912995 . 10.1074/jbc.M211719200 . vanc. Beato M . Groot-Kormelink PJ . 3 . Broadbent . SD . Sivilotti . LG . free.
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Anand R, Lindstrom J . Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans . Genomics . 13 . 4 . 962–7 . Sep 1992 . 1505988 . 10.1016/0888-7543(92)90008-G .
2. Web site: Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3.