CHMP5 explained

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.^{[1] [2] [3]}

Function

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.^{[3] [4]}

Further reading

• Lai CH, Chou CY, Ch'ang LY . Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 . etal.
• Zhang QH, Ye M, Wu XY . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Strack B, Calistri A, Craig S . AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding . Cell . 114 . 6 . 689–99 . 2003 . 14505569 . 10.1016/S0092-8674(03)00653-6 . 10733770 . etal. free .
• von Schwedler UK, Stuchell M, Müller B . The protein network of HIV budding . Cell . 114 . 6 . 701–13 . 2003 . 14505570 . 10.1016/S0092-8674(03)00714-1 . 16894972 . etal. free .
• Martin-Serrano J, Yarovoy A, Perez-Caballero D . Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins . Proc. Natl. Acad. Sci. U.S.A. . 100 . 21 . 12414–9 . 2003 . 14519844 . 10.1073/pnas.2133846100 . 218772 . 2003PNAS..10012414M . etal. free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J . The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells . J Biol Chem . 280 . 11 . 10548–55 . Mar 2005 . 15644320 . 10.1074/jbc.M413734200 . free .
2. Howard TL, Stauffer DR, Degnin CR, Hollenberg SM . CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins . J Cell Sci . 114 . Pt 13 . 2395–404 . Sep 2001 . 10.1242/jcs.114.13.2395 . 11559748 .
3. Web site: Entrez Gene: CHMP5 chromatin modifying protein 5.
4. Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM . A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex . Genomics . 88 . 3 . 333–46 . September 2006 . 16730941 . 10.1016/j.ygeno.2006.04.003 .