NE-CHMIMO explained

NE-CHMIMO (CHM-018) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^{[1] [2] [3]} NE-CHMIMO is the 1-cyclohexylmethyl (instead of 1-pentyl) analogue of the first-generation synthetic cannabinoid JWH-018. The corresponding cyclohexylmethyl derivative of JWH-081 had also been reported several months earlier.^[4]

Legal status

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as NE-CHMIMO are Schedule I Controlled Substances.

NE-CHMIMO is a controlled substance in Japan as of November 2019.^[5]

Notes and References

1. Angerer V, Bisel P, Moosmann B, Westphal F, Auwärter V . Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative "NE-CHMIMO" using flash chromatography, GC-MS, IR and NMR spectroscopy . Forensic Science International . 266 . e93–e98 . September 2016 . 27297324 . 10.1016/j.forsciint.2016.05.031 .
2. Franz F, Jechle H, Angerer V, Pegoro M, Auwärter V, Neukamm MA . Synthetic cannabinoids in hair - Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples . Analytica Chimica Acta . 1006 . 61–73 . May 2018 . 30016265 . 10.1016/j.aca.2017.12.029 .
3. Web site: NE-CHMIMO . New Synthetic Drugs Database.
4. Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J . Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense . Forensic Science International . 260 . 40–53 . March 2016 . 26795397 . 10.1016/j.forsciint.2015.12.001 . free .
5. Web site: 2019-12-22. 指定薬物を指定する省令が公布されました｜厚生労働省. Ministry of Health, Labour and Welfare. ja. www.mhlw.go.jp.