CGS-9896 explained

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.^[1]

CGS-9896 is a benzodiazepine receptor partial agonist which produces long-lasting anxiolytic and anticonvulsant effects in animal studies but does not produce sedative effects.^{[2] [3]} It also increases appetite,^[4] and reduces the development of gastrointestinal ulcers following chronic stress.^[5]

Notes and References

1. Leidenheimer NJ, Schechter MD . Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex . Pharmacol Biochem Behav . 31 . 2 . 249–54 . Oct 1988 . 2854261 . 10.1016/0091-3057(88)90342-5. 21773709 .
2. Bernasconi R, Marescaux C, Vergnes M . Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models . J Neural Transm . 71 . 1 . 11–27 . 1988 . 3343593 . 10.1007/BF01259406 . 31525533 . etal.
3. Rump S, Raszewski W, Gidynska T, Galecka E . Effects of CGS 9896 in acute experimental intoxication with fluostigmine . Arch. Toxicol. . 64 . 5 . 412–3 . 1990 . 2206111 . 10.1007/BF01973465 . 19084019 .
4. Chen SW, Davies MF, Loew GH . Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake . Pharmacol Biochem Behav . 51 . 2–3 . 499–503 . 1995 . 7667375 . 10.1016/0091-3057(95)00020-W. 32809713 .
5. Najim RA, Karim KH . Effect of CGS 9896 on stress-induced gastric ulcer in rat . Clin Exp Pharmacol Physiol . 17 . 2 . 157–161 . Feb 1990 . 2109664 . 10.1111/j.1440-1681.1990.tb01298.x . 37492286 .