CFU-GM explained

CFU-GM
Location:	Bone marrow
Function:	colony forming unit
Givesriseto:	Monoblasts and myeloblasts

CFU-GM (Colony Forming Unit–Granulocyte–Macrophage), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).

Granulocytes

There is some controversy over which granulocytes derive from CFU-GM.

• There is little disagreement that neutrophils come from CFU-GM.
• Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".^[1]
• Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".^[2]

See also

• Hematopoietic stem cell § Nomenclature of hematopoietic colonies and lineages

Notes and References

1. Book: Ganong, William F. . McPhee, Stephen J. . Lingappa, Vishwanath R. . Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange) . McGraw-Hill Medical . 2005 . 107 . 0-07-144159-X .
2. Book: Rudolph, Colin David . Rudolph's pediatrics . McGraw-Hill, Medical Pub. Division . New York . 2003 . 1563 . 0-8385-8285-0 .