CFHR4 explained

Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.^{[1] [2] [3]}

Further reading

• Hageman GS . Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications . Ann. Med. . 38 . 8 . 592–604 . 2007 . 17438673 . 10.1080/07853890601097030 . 1905836 . vanc. Hancox LS . Taiber AJ . 3 . Gehrs . Karen M. . Anderson . Don H. . Johnson . Lincoln V. . Radeke . Monte J. . Kavanagh . David . Richards . Anna .
• Józsi M . FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene . Eur. J. Hum. Genet. . 13 . 3 . 321–9 . 2005 . 15562282 . 10.1038/sj.ejhg.5201324 . vanc. Richter H . Löschmann I . 3 . Skerka . Christine . Buck . Friedrich . Beisiegel . Ulrike . Erdei . Anna . Zipfel . Peter F . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Hellwage J . Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin . FEBS Lett. . 462 . 3 . 345–52 . 2000 . 10622723 . 10.1016/S0014-5793(99)01554-9 . vanc. Jokiranta TS . Koistinen V . 3 . Vaarala . O . Meri . S . Zipfel . PF . free .
• Hellwage J, Skerka C, Zipfel PF . Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4) . Immunopharmacology . 38 . 1–2 . 149–57 . 1998 . 9476126 . 10.1016/S0162-3109(97)00075-1 .

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome

Notes and References

1. Skerka C, Hellwage J, Weber W, Tilkorn A, Buck F, Marti T, Kampen E, Beisiegel U, Zipfel PF . The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins . J Biol Chem . 272 . 9 . 5627–34 . Apr 1997 . 9038172 . 10.1074/jbc.272.9.5627 . free .
2. Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D . A radiation hybrid map of complement factor H and factor H-related genes . Immunogenetics . 49 . 6 . 549–52 . Jul 1999 . 10380701 . 10.1007/s002510050534 . 31776506 .
3. Web site: Entrez Gene: CFHR4 complement factor H-related 4.