CFHR3 explained

Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene.^{[1] [2] [3]}

Further reading

• Zipfel PF, Skerka C . Complement factor H and related proteins: an expanding family of complement-regulatory proteins? . Immunol. Today . 15 . 3 . 121–6 . 1994 . 8172644 . 10.1016/0167-5699(94)90155-4 .
• Hellwage J, Jokiranta TS, Koistinen V . Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin. . FEBS Lett. . 462 . 3 . 345–52 . 2000 . 10622723 . 10.1016/S0014-5793(99)01554-9 . 41308410 . etal.
• Male DA, Ormsby RJ, Ranganathan S . Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. . Mol. Immunol. . 37 . 1–2 . 41–52 . 2000 . 10781834 . 10.1016/S0161-5890(00)00024-9 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Zipfel PF, Edey M, Heinen S . Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. . PLOS Genet. . 3 . 3 . e41 . 2007 . 17367211 . 10.1371/journal.pgen.0030041 . 1828695 . etal . free .

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome

Notes and References

1. Skerka C, Kuhn S, Gunther K, Lingelbach K, Zipfel PF . A novel short consensus repeat-containing molecule is related to human complement factor H . J Biol Chem . 268 . 4 . 2904–8 . Mar 1993 . 10.1016/S0021-9258(18)53859-X . 8428964 . free .
2. Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D . A radiation hybrid map of complement factor H and factor H-related genes . Immunogenetics . 49 . 6 . 549–52 . Jul 1999 . 10380701 . 10.1007/s002510050534 . 31776506 .
3. Web site: Entrez Gene: CFHR3 complement factor H-related 3.